Risk of Stroke in Relation to Degree of Asymptomatic Carotid Stenosis: A Population-based Cohort Study, Systemic Review, and Meta-analysis

Prospective, population-based study (Oxford Vascular Study) between April 1, 2002, and 2017, a systematic review using MEDLINE, Embase, the Cochrane Central Register of Controlled Trials January 1980, October 2020. In study, patients with 70% to 99% asymptomatic stenosis had significantly greater 5-year ipsilateral stroke risk (15% [6/53]) than those 50% 69% (0% [0/154]), as did 80% (18% [6/34]) compared 79% (1.0% [2/173]). systemic review, in was higher (10% [386/3778]) (5% [181/3,806 patients]), (11% [77/727]) [167/3272]). The reported cohort studies highly dependent on degree carotid stenosis, suggesting that benefit endarterectomy (CEA) might be underestimated severe stenosis. Conversely, low for moderate contemporary medical treatment, calling into question any from revascularization less